https://www.metabolomics.strath.ac.uk/Metabolomics.htm

Metabolomics and Metabonomics - Just more omics?

Metabolomics and metabonomics have seen a surge in popularity in recent scientific research. They may seem like two interchangable terms, with some groups favouring one over the other, but there is some difference between the two terms. Metabolomics as defined by Oliver Fiehn involves "...a comprehensive analysis in which all the metabolites of a biological system are identified and quantified..." whereas Metabonomics was defined by Jeremy Nicholson as "the quantitative measurement of the multiparametric time-related metabolic responses of a complex (multicellular) system to a pathophysiolocigal intervention or genetic modification." In other words, metabolomics is the process of measuring the whole metabolome, whereas metabonomics is the measurement of changes across the metabolome, with respect to time, due to an intervention, which is a smaller set of metabolites.

Both metabolomics and metabonomics have seen an increase in research over the past decade, to the point where metabolomics now has a dedicated journal. Studying the metabolome can give an insight into genetic or enviromental changes and can provide valuble information to researchers to support genomic, transcriptomic and proteomic data sets.

More info: Chapter Metabolomics and Metabonomics

Thank you so much respected Professor Nikolay Vassilev .

Hi Akram,

For detail insight into you can refer this literature, titled..

Systems level studies of mammalian metabolomes: the roles of mass

spectrometry and nuclear magnetic resonance spectroscopy.

Article ChemInform Abstract: Systems Level Studies of Mammalian Meta...

Thanks Buddhadeb Chandra

Metabolism is the ensemble of chemical transformations carried out in living tissue (§10.2); operationally it is embodied in the matter and energy fluxes through organisms. Metabolomics is defined as the measurement of the amounts (concentrations) and locations of the all the metabolites in a cell, the metabolites being the small molecules (Mr 1000; e.g., glucose, cAMP,1 GMP,2 glutamate, etc.) transformed in the process of metabolism (i.e., mostly the substrates and products of enzymes).3 The quantification of the amounts of expressed enzymes is, as we have seen, proteomics; metabolomics is essentially an extension of proteomics to the activities of the expressed enzymes, and it is of major interest to examine correlations between expression data and metabolite data.4 Metabonomics is a subset of metabolomics and is defined as the quantitative measurement of the multiparametric metabolic responses of living systems to pathophysiological stimuli or genetic modification, with particular emphasis on the elucidation of differences in population groups due to genetic modification, disease, and environmental (including nutritional) stress. In the numerous cases of diseases not obviously linked to genetic alteration (mutation), metabolites are the most revealing markers of disease or chronic exposure to toxins from the environment and of the effect of drugs. As far as drugs are concerned, metabonomics is effectively a subset of the investigation of the absorption, distribution, metabolism, and excretion (ADME) of drugs.

For further detail read the book ( Bioinformatics) written by Jeremy Ramsden

Hello

https://www.metabolomics.strath.ac.uk/Metabolomics.htm

metabolomics is the process of measuring the whole metabolome, whereas metabonomics is the measurementof changes across the metabolome, with respect to time, due to an intervention, which is a smaller set of metabolites.

Thanks

Dear Salah,

Frequently, the terms are used as if they were sinonymous. The two strategies make use of homeostasis principle - changes in the profile of endogenous metabolites due the action of an external agent, as a disease... But, there is one conceptual difference that results in operational difference. In the METABOLOMICS, it is necessary to identify and do absolute quantification of all endogenous metabolites associated to action of external agent; while in the METABONOMICS, the objective is to identify a metabolic fingerprint. This conceptual difference implies in the use of analytical tools different.

Normally, Metabolomics strategy uses mixtures separation tools, as HPLC or GC hyphenated to MS. As there is not necessary absolute quantification, it is more frequent the use of NMR spectroscopy in Metabonomics studies.

This is also associated to research groups that created the terms. Metabonomics was created by Nicholson, Holmes and Lindon (NMR); while Metabolomics was created by Fiehn and reseachers who work with GCMS and HPLC-MS.

Thanks you so much Ricardo O Silva

Metabolomics is Identification and Quantification of entire metabolites in the biological system, but Metabonomics is the quantitative measurement of metabolic response of biological system to the stimulant or genetic modification.

Metabolomics is the systematic study of small molecules (metabolites) in a living system and their interactions.

Metabonomics is the quantitative measurement of time taken for a metabolic response in a living system to occur following a pathophysiologic stimuli or a genetic modification.

Thanks @ christopher Nwoji

Thank you so much for your time @ Rahmatollah Rajabzadeh

Thanks Muhammad Atif Wahid