Hello,

Im developing new organocatalyst for asymmetric reactions and in case my catalyst I observe:

a) Lowering cat. loading INCREASE ee of the product

b) Lowering temperature DECREASE ee of the product

Those two seem rather odd, because usually its the other way ie. low temp = better ee and loading seem to have small effect until some borderline loading is reached and after that the ee drops.

Can you suggest some kind of possible explanation or even lit. reference if you know about similar case?

Of coure there MIGHT be some kind of experimental error but I replicated the experiments few times and got from 30%ee at 20% loading to 50% ee at 1% loading.

Thank you

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