Look at Rosser and Scoenfeld, Approximate Formulas for some function of prime numbers, Illinois J. of Math. 6 (1962), 64-94. Theorem 4 in that paper states that the sum of the logs of the primes up to x is greater than
x(1-1/(2 log x)) for x greater than or equal to 563.
Exponentiate to get the result on the product of primes.