Recent work on DMMC, has led me to the concept that meta-stability of brain waves has to do with facilitation of various memory systems. But this seems to lead to the idea that facilitation is global rather than specific to a particular neuron. The question then becomes, if a cell is not firing, what does activation of the facilitation mechanism do? Is it possible that facilitation is globally activated but only affects firing neurons?
I know that in the case of NMDA receptors, they are voltage dependent and do not activate unless the cell is firing, but what about the less sophisticated S synapse? is it voltage dependent as well?
To Add to the confusion, some studies suggest that LTD is the result of LTP triggering signal arriving before the cell fires. Is there a similar depressive effect with the S synapse, and if so, is there evidence that the in situ neurons are not depressed normally?
You may find this helpful:
https://www.researchgate.net/publication/50194883_Synaptic_plasticity_a_unifying_model_to_address_some_persisting_questions?ev=prf_pub
Article Synaptic Plasticity: A Unifying Model to Address Some Persis...
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