Dear All,
I am working on development of novel pre-clinical models for autism. I have recently submitted a manuscript for my work where I got a reviewer's comment stating "The issue above also raises the importance of testing and characterization of false positive and false negative controls in the model is required to understand the specificity of the model. A more complete exploration of multiple compound, including both positive and negative controls would help to define the value of this screening model."
From the above comment I understand that we need to screen more compounds to prove the specificity of the model. However, I am confused with the negative control drugs. Do negative control drug here means the drug acting on CNS but not in autism or any random drug having no effect on CNS ?
Regards
Shubham Dwivedi
Negative control means group which do not receive any treatment.... positive control is the group which receive known treatment
Negative Control: is an experiment that uses the same procedures as a primary experiment at the same time on a different population with a placebo or no treatment. This is predicted to produce no change to results of interest to the experiment.
Positive Control is a parallel experiment on a different population. The treatment used in a positive control has a well understood effect on results. A positive control is typically a treatment that is known to produce results that are similar to those predicted in the hypothesis of your experiment.
Example: An experiment for a new medication to treat a disease uses a placebo as a negative control and a commercially available medication as a positive control. The negative control is used to show that any positive effects of the new treatment aren't the result of the placebo effect. The positive control is used to detect any problems with the experiment and to benchmark results against another medication.
normal control: mean health group no diaseas induction no treatments.
negative control: group with induced disease without treatment.
positive control : induce disease and treated by known standard drug.
Dear All,
Thank you for the response. But here my concern is not about the definition of negative control. The reviewer in the comment mentions about negative control drug. I wonder what negative control drug means?
Regards
Shubham
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