Please explain here with references about what will be effect of contractile agent in endothelium denuded aorta over PE?

When we say the contraction is endothelium dependent and endothelium independent?

If contractile agent is able to cause contraction over PE in endothelium intact aorta. Is it possible that same concentration of contractile agent will not cause any contraction in endothelium denuded aorta?

If this happens what will be your interpretation?

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