UV rays are known since ages. How is the pollution today affecting skin sensitivity to sunlight?
The cause of PLE is not yet understood. It is thought to be due to a type IV delayed-type hypersensitivity to an allergen produced in the body following sunlight exposure. It can be provoked by UVA or UVB rays. Some progression to autoimmune disease has been observed. Pathogenic strains of H. pylori have been shown to
activate the epidermal growth factor receptor (EGFR), a membrane protein with a tyrosine kinase domain. Activation of the EGFR by H. pylori is associated with altered
signal transduction and gene expression in host epithelial cells that may contribute to pathogenesis.
Bashir A. H. H.1,2*, Yousif S. M.2 and Mahmoud M. O. A.2. Clinicoepidemiological study in Sudanese patients: Prevalence and effect of eradicative triple therapy on
extra digestive Helicobacter pylori skin manifestations, EdHpSm. Clinical Reviews and Opinions Vol. 3(2), pp. 14-19, February 2011.
Available online http://www.academicjournals.org/cro
ISSN 2141-2553 ©2011 Academic Journals
"the underlying reason for the occurrence of the disorder in any given patient appears likely to be genetic , perhaps 70 per cent of all subjects having a tendency to the condition , but its actual expression depends on the degree of gene penetrance ." ( HAWK J , NORRIS PG . HONIGSMANN H )
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