Biologics have made a revolutionary change in the course of immune-mediated diseases especially psoriasis. It's still very young to judge the long-term effects of this type of therapy, but from your understanding to the human immune system and its non-ending tricks, what can be the consequences?
Madame, actually we know TNF-alpha inhibitors make a latent tubercolosis infection blow up as well as omalizumab is associated to an increased incidence of arterial thrombotic events as reported by US Food and Drug Administration (FDA), after having collected the adverse events since January 2004 to January 2011 (see: Ali AK, Hartzema AG. Assessing the association between omalizumab and arterio-thrombotic events through spontaneous adverse event reporting. J Allergy Asthma 2012, 5: 1–9. Efalizumab was withdraw from market because causing drug induced aseptic meningitis and polyneuropathies, but it is too early to establish know other delayed side effects of biologics
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