Please can you explain what you mean by a cancer dormant phenotype?

Because phenotype is something expressed, something you can see with the microscope or measure it in the lab. Its there and is self evident.

May be you are refering to dormant cancer genotype?

Hi, this is a general question, please explain a bit more in details....

You can probably start with the

The Cancer Genome Atlas - Cancer Genome - TCGA

https://cancergenome.nih.gov/

Hello All,

Thank you for your contributions, and let me apologise for not stating the question more clearly.

For clarification:

- I understand that the phenotype is dormant, and that is exactly what I am investigating - what is responsible for this?

- I want to understand what proteins or other cellular molecules, as well as what microenvironmental cells are involved in triggering this shift to dormancy

- As you can understand, there are many different molecules and cells to look at, and as such, I was inquiring as to assessing the best path forward using bioinformatics to analyse laboratory data as to which cells/molecules are most strongly implicated or to provide an analysis from existing databases to narrow down molecules/cells

- As a beginner to bioinformatics, I was wondering what approaches, what software, what analyses can be used to best refine my approach to understanding tumour dormancy

Examples of this would be Principle Component Analysis, or Gene Network Analysis

Thanks!

I hope I have provided a clearer question now