In the last few months, trying to conjugate the dodecanol (DC) chain with the carboxylic units (30 units) of poly(ethylene glycol)–poly(2-methyl-2-carboxyl-propylene carbonate) via several esterification methods, but a maximum of 15 units of DC were grafted.

1. EDC or DCC/DMAP, N2 24 or 48 h

2. EDC/Hobt/ DIPEA, N2 RT 48/ 72 h

All reagents used are anhydrous, and 3/3 cycle vacuum/N2 conditions are followed before the commencement of the reactions.

Please find attached an article related to my work.

Request suitable suggestions.

Thanks in advance.

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