In the last few months, trying to conjugate the dodecanol (DC) chain with the carboxylic units (30 units) of poly(ethylene glycol)–poly(2-methyl-2-carboxyl-propylene carbonate) via several esterification methods, but a maximum of 15 units of DC were grafted.
1. EDC or DCC/DMAP, N2 24 or 48 h
2. EDC/Hobt/ DIPEA, N2 RT 48/ 72 h
All reagents used are anhydrous, and 3/3 cycle vacuum/N2 conditions are followed before the commencement of the reactions.
Please find attached an article related to my work.
Request suitable suggestions.
Thanks in advance.