Short answer: I don't know.

Longer answer: There is potential for designs to be more physics or performance based than they have been in the past because there are less restrictions to fabricating buildings. The mathematics of optimization and solution of inverse problems is well established. The problem is that classical building doctrine is based on lots of experience, most of which is not encoded into the conclusions. To be superior, PBSD will have to optimize along several axes simultaneously, and the designer will have to capture all failure modes. I suspect there will be some (more) spectacular failures before the new design doctrine is established.

I will be starting a project soon on improving aerostructures using additive manufacturing and meta-materials, so I hope to be better informed in a year or so, but for now, I don't really know.