The very important index used to detect the pollution of seawater is Phytoplankton. It's a very sensetive element to the envirment perturbations (Goffart, 2010; de Jonge et al. 2002, Devlin et al. 2007).
A monitoring of microalgaes (phytoplankton) is very usefull because of the appearence of some species known to plorifate quickly in pollution conditions. The result of monitoring can, also, be used to calculate a lot of Indexes, for mesuring the stability of the phytoplankton in marine envirment, such Shannon Index which is very usefull by researchers.
You can also use the shellfish as bioindicators if you want to detect trace metal elements pollution ( Amiard et al., 1985 et 1994; Guevara et al., 2004; Foxall et al., 2000; Abarnou et al., 2013; Bélanger et al., 2009; Kruzynski et al., 2002; Yap, 2007).
All above suggestion is right, this are standart methods. But real (sinergetic) toxicity you can determing only by biological methods, for example using species-indicator bivalva mussels. If water polluted, the animal close shells and heart activity stay slow. But the methods don't answer what elements present in water. New bioelectronic devices can registrate the parameters. If it interesting I can send materials [email protected]