What are the different ways of producing purified/downstream processing of recombinant human insulin from E.Coli?

23 May 2016 1 3K Report

Chemical Engineering, Pharmaceutical Engineering, Downstream Processing, Purification, E.Coli, Pharmeceutical, Process engineering, Biochemical Engineering, Microbiology

Craig Robinson

While I have no first hand experience developing an insulin purification process, I've spoken with others who have. I'm told that there are many different insulins and that the process required to achieve an injectable quality drug is extremely complex. Early processes used by the leading suppliers had as many as 27 steps in downstream. Chromatography suppliers such as GE Healthcare have related experience and appropriate products to begin to develop such as process. Good luck, Craig

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