I'd like to add to my recommendation of Kay's answer by pointing it out as a model of complete, informed and and informative responses to a question. I often find a lot of answers to questions on research gate are of the 'me too' variety (repeating what has already been said) or, while well meaning, are based on limited knowledge and expertise. Often people just take an opportunity to promote their own work or add their own issues (perhaps what I am doing now!). Perfect answer - well done and thanks. It was a good question and the answer was 100% informative for anyone interested in it.