This is a very broad question. There are probably hundreds if not thousands of research problems to be solved. The range includes:

1. How to conduct genome-clinical correlations on a large scale

2. What are the best ways of providing clinical decision support to providers and patients?

3. What are the privacy preserving technologies that will let patients be comfortable in sharing their data for research?

4. What are the principles and mechanisms of incorporating health information technologies into organizations in ways that increase provider productivity and increase patient safety?

5. What are the best ways to visualize population-based information for communication to clinicians and policy makers?

I could go on. What area where you thinking about specifically?