We are using a gold nano rod platform to photo dynamically kill bacterial cells. I am currently looking for targeting agents that I can easily couple to the Au Nano rod base and are effective for E coli targeting. Using antibodies to target bacteria is a less desired option because of their size and multiple active functional groups that hinder with the coupling of "drug" that we are using to kill bacteria.
Any insights in this regard will be greatly appreciated. Thank you!
Hi Mohammad Azhar Mehfooz . You could try polymyxin B and protamine. Both bind LPS and have free amino groups that can be coupled to Au using Traut's reagent (2-iminothiolane).
Thank you Dr. Steingrimur Stefansson! Polymyxin B has been in my list too. I'll look over more literature for protamine.
Hi Mohammad Azhar Mehfooz . Neomycin and bacitracin also qualify.
I hope this works for you and evokes interest in larger Pharma companies.
I am willing to help if this takes off, Take a look at my profile. I have written grants and given presentarions to the FDA.
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