Firstly, you have to define the system under optimization. If this section you said is part of greater industrial facility, I would recommend to consider the total industrial facility for the optimization. The optimum condition for each element of a system, taken together will not represent the optimum of the system as whole.
After that, you should start modeling the components of the industrial flow-sheet. You can use phenomenological models or empirical ones. In this last case statistical procedures such as Evolutionary operations (EVOP) could be used at industrial scale
It is important to clearly define a proper objective function and good constrains to limit the solution to feasible conditions.
For me, optimization by computer simulations is the best when ever possible. I recommend MATLAB software to do this.
The process is pretty simple 1) Identify constraints, 2) Operate as close to constraints as possible 3) Remove constraints (operating changes or investment)
It is necessary to invest in new technical solutions, new technologies, automation of production processes, minimizing the failure of equipment, introducing simplified technological solutions. Raising the qualifications of employees.