Good evening.
I am working on my bachelor’s thesis and i need some informations about water solubility of Drotaverine HCl.
I couldn’t find something usefull not even on chemistry websites.
Thank you for your help !
Drotaverine (hydrochloride) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous
buffers, drotaverine (hydrochloride) should first be dissolved in DMF and then diluted with the aqueous
buffer of choice. Drotaverine (hydrochloride) has a solubility of approximately 0.16 mg/ml in a 1:5 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Drotaverine is sparingly soluble in water. In DMF/PBS 1:5, the solubility is 0.16 mg/mL. See https://www.caymanchem.com/pdfs/20944.pdf
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