Everybody process D3 to hydroxylase-25 at different rates. It is my opinion that optimal health is achieved when an individual has a D3 level of between 70 - 100 mg/ml. Liver enzymes need to be carefully monitored to assure the most effective conversion of D3 to hydroxylase-25. A compromised liver may require higher dosing of D3 in order to have effective anti-inflammatory respose.

https://pubmed.ncbi.nlm.nih.gov/32252338/

Intersting

Article Evidence that Vitamin D Supplementation Could Reduce Risk of...

Vitamin D and immunity are allways in match ! Vitamin A too ! They are working together to regulate transcription for many genes , including for various signaling in immunity ! Also they are directly acting as transductors from electromagnetic energy (light) to organic materia and metabolism chemistry. That set them back in time close to origins of life on the earth , when translating light into organic materia was a retinoid matter (RAL) ,far before the chlorophyle right ? I'm sure these two vitamins will be precious (and afordable) public health tools in fighting any infectious pandemia, including the COVID-19 for now. To follow and explore !!!

PS .Anecdoticaly that would give a point to President Trump as for light beeing a tool in fighting COVID-19 ! Sun light longer exposure in summer than in winter clearly raise the vitamin D tegumentary synthesis. Let's hope immunity tools too !

Vitamin D is known as the sunshine vitamin because it is produced in the skin by exposing the body to just 10-15 minutes per day of sunshine.This vitamin plays an essential role in preventing respiratory infections, reducing antibiotic use, and boosting the immune system's response to infections.

Vit.D and immune system are always in match.

So,good Vit.D, good immunity and more fighting capability against this deadly virus in case.

It would be convenient to give especially in old people and in regions with few hours of sunshine daily

Some of my findings

https://www.researchgate.net/project/The-Coronavirus-Files

https://drive.google.com/file/d/1VNPo5TzLmf9YZh_o9D8Ck6j2hipaZBWw/view?usp=drivesdk

A vitamin D3 dose of 5000IU/d is safe and should get most adults to 40ng/ml. Some hospitals, medical clinics and physician offices have reopened for routine care (with facemarks). Children should also be taking D3 supplements: 1000-2000+IU/d depending on age and weight. With sufficient vitaminD, calcium supplementation is likely unnecessary, especially with the review of calcium scores on chest CT scans suggesting oral supplements may "metastasize" to the coronary vessels as an explanation for the high scores. As long as the daily dose is below 10,000IU/d, hypercalcemia and renal stones should not be a problem.

Question: why would anyone be comfortable with a borderline low D3 level, especially in this time of COVID-19 when higher serum levels have immune protection (70-80ng/ml for MS)?

For adults dosage of 0.266 mg in smooth capsules twice a month is recommended

https://link.springer.com/article/10.1007/s40520-020-01570-8

https://www.news-medical.net/amp/news/20200514/Does-vitamin-D-deficiency-increase-COVID-19-risk.aspx

Your proposal needs a research study that determines the required dosages and according to ages as well as according to different physiological conditions, as well as the measurement of biochemical parameters.

All good answers.

Overdosage can lead to milk-alkali syndrome.

More is not better.

There are reports of people taking massive doses and hoarding.

This is just stupid.

Best,

Jerry

We all know the vitamin D basics needs. But there is more to it than just healthy bones, when about immunity. The Vitamin D to immunity contribution is the next « norma » that overpasses the regular diet intake, driving us to molecular nutrition. There is more & more évidence that vitamin D intake (whatever diet, supplements or both) should be optimised, in a Comparative Systemic Integration model, with several variants. Such as : geographic Latitude, outdoor real exposure, tegumentary melanin, cultural outfits and diets and perhaps many more. The goal beeing to reach both , healthy skeleton AND top shape immune system. Not to talk about sexual hormones, all related to as well. Long way to go still , right ? Speaking about COVID19, we are to compile vitamin D status in some fragile population in Montréal and our preliminary data are not encouraging for the immunitary needs in Vitamin D. All subjects, including the healthy controle group, are dysbalanced for the immunitary needs in Vitamin D. Do you remember Montréal is Lat.45.5 North ? By chance the Summer starts right now ! We'll see !

Daniel:

There is a disruptor in your equation: studies that find no or little benefit form vitamin D supplements, especially those labeled "high dose" start with a lower limit of "normal" that is too low and a "high dose" supplement that is not high and , actually, is inadequate, so the studies are invalid from the beginning. Enclosed is such a sample with my reply.

Abstract

Background & Aims

Vitamin D deficiency is common in Crohn’s disease (CD). High-dose vitamin D had anti-inflammatory effects in preclinical studies and trials of patients with CD. We performed a randomized trial to determine whether high-dose vitamin D prevents postoperative recurrence of CD after ileocolonic resection.

Methods

Patients with CD following ileocolonic resection with ileocolonic anastomosis were randomly assigned to groups given weekly 25,000 IU oral vitamin D (n=72) or placebo (n=71) for 26 weeks, at 17 hospitals in the Netherlands and Belgium from February 2014 through June 2017. Patients were assessed at baseline and week 2, 6, 12, and 26 for laboratory and clinical parameters, and underwent ileocolonoscopy at 26 weeks. The primary endpoint was endoscopic recurrence (modified Rutgeerts score ≥i2b, assessed by blinded readers) at 26 weeks. Secondary endpoints included clinical recurrence (Crohn’s disease activity index ≥ 220), quality of life (measured by SF-36, IBD-Q and EQ-5D) and outcomes associated with baseline serum concentration of vitamin D.

Results

In the vitamin D group, serum levels of 25-hydroxy vitamin D increased from median 42 nmol/L at baseline to 81 nmol/L at week 26 (P

You are absolutely correct.

How much is too much is good to know. However, I stand by my comments about more is better and hoarding is unfair.

Best,

Jerry

Yup ! Thats another proof, caution is to be observed when using... adjectives...without defining proper references first. Vitamins field or else !

As Dr. Pauling used to say : There's more to Vitamin C than avoiding scorbut ! As well for the vitamin D over just strenghtening bones. The end of the day, the eventualy needed supplement amount comes down to be very personal. Thanks !

And Dr. Pauling did not have it quite right. It has been shown that over 500mg of a dose of vitamin C makes it pro-oxidant. He died of prostate cancer, but not necessarily caused by vitamin C. Presently vitamin C infusions of 25g-100g are in vogue for treating autoimmune disease and cancer with apparent efficacy but without the evidence basis for it. I wonder if Dr. Pauling took vitamin D and selenium supplements as there is evidence basis for prevention of prostate cancer. In addition, vitamin D is associated with a lower incidence of colorectal and breast cancers. Certain supplements can be life enhancers and life savers. There is more, but

I rest my case here.

This is very important to normalize the serum levels of vit D in order to improve the anti-inflammatory and immunologic responses of the body against the viral infection

For sure he did, given his book « How to live longer and live better ! ». I guess big progress will be made while in adressing Dr. Pauling missings ! And that is what hot when about science : It's allways a journey beauty in a neverending story ! We nevertheless have to admit a Nobel prise is a mile-stone that deserves some consideration. When it comes to ... TWO Nobel Prizes...it must be more than just luck or conincidence, right ? Conclusion : Scientifique dialogue is very important and emotionals biais are to be acknowledged ...and managed toward strong reference ! Back to Vit D : Supplementation is a multivariant personalised story !

One capsule of vitamin D every 15 days during six months would be enough

On a daily base, a dose of 4000 iU (100 microgram) is sufficient to reach a 25-OH D3 concentration in bloodserum somewhere between 100 and 150 nmol/L being high-normal.

There is no need to give any higher daily doses. Only in patients with initial deficiency (less than 50 nmol/L) or severe deficiency (less than 25 nmol/L) a boost dosis of 100 - 300.000 iU is advisable. An alternative in case of initial deficiency would indeed be to give 8000 iU / d for some weeks, measure 25-OH D3 in blood and adapt the dose as suggested by Bleisgyz.

I used to take 5000 IU vit. D per week, it is good we need it

I used to give patients about 800 - 1200 IU / day

I take 6,000 IU/day to get my D3 blood level to 55ng/ml. I have treated my osteopenia for 15 years now with supplementation and, in addition, I am treating my immune deficiency that was nearly fatal in the past.

I'm going with 3000 IU /day for now. Yet, the fact I expose 30 min/day my legs, arms and face to natural sunlight must be considered as a plus, somehow. I am seriously thinking about a « pandemia s » trio, such as : A) 3000 IU / day , for virus free people, as longterm prevention , B) Positive CoV2 tested people but asymptomatic : up grade to 6000 UI / day for a minimum of 14 days & check the symptoms C) First symptoms COVID similar : up grade to 9000 UI / day for at least 4 days and follow up symptoms. Probably backed up by some antioxydant package as Selenium+Vit. A, C, E and hydratation at will. Just a thought :) DCM

Daniel,

vitamin D is a preventative. If you have CODI-19, it will not be of benefit increasing the dose. The same with zinc and probiotics to enhance the immune system (prevention, not treatment

I do agree Dr. Helman ! But with so many peoples' low Vit D blood values, and considering fever, dehydratation and anorexia are reducing absorbtion, membrane transfert and metabolism , I made the assumption for a secondary prevention need. Within reasonable range of course. Best, DCM

It is a good recommendation because the supplements of vit D enhance the immunity and the response against many infections

Vitamin D is good for autoimmune disease and even helps to fight with the common cold and flu, however, if someone has kidney issues then vitamin D supplements are not recommended. Therefore, before taking any supplements or vitamins, it is important to check with your doctor.

Vitamin D protects our body from various infections and illness. For this very reason, it is more important for our body as people are advised to stay at home. This means that they would be getting less vitamin D.

In one of the recent study of Coronavirus (COVID-19), it was observed that the mean level of vitamin D among the infected people was low and was associated with the number of mortality rate

Vitamin D levels are low in the older people hence they are more prone towards Corona infection. Healthcare officers are also recommending the intake of Vitamin D (as per your doctor’s consultation).

Researchers are continuously working on finding the direct relation of vitamin D if it can reduce the infection of coronavirus and if vitamin D is beneficial in pandemics. Because vitamin D is helpful for health.

Another study suggests that if people have vitamin D deficiency, their outcomes for coronavirus maybe more.

Researchers from Spain and France are working on clinical trials to see the potential role of vitamin D in case of corona diseases.

Vitamin D is beneficial for the immune system as well, as it reduces the anti-inflammatory responses because in case of coronavirus if the immune response is high and cytokines are released more, it’ll affect the lungs more.

This can be a great help for prevention and treatment of these patients

Dear researchers I searching for data, support, and explanations for the dramatic worst mortality data of Lombardia (N. Italy) in the first pandemic phase. Thanks for possible aid.

https://www.researchgate.net/post/The_novel_Coronavirus_in_N_Italy_Lombardia_COVID19_2019nCoV_SARSCoV2_shows_a_fatality_rate_compatible_with_SARS-MERS_Why

Linked pre-print papers: https://www.researchgate.net/publication/341325862

Stay safe --sv--

Dear Colleagues, I just published an article on that thema (accepted version):

Article Vitamin D and COVID‐19: It is time to act

Congratulation ! Very important given a Vitamin D deficiency is documented as beeing associated, among others, with reduced lymphocytes in number, slow differentiation of monocytes to macrophages and lower phagocytic ability of same macrophages, thus increasing infections' incidence and severity ! We are on a Vitamin D status populational snap evaluation here in Montréal right now ! Just like in many Northern countries, the preliminary data are pointing on mild to high insuficiency ! We are still compiling the data , but if the general picture is consistent, even if not severe deficiency, that would still be a serious public health problem under present viral pandemia circumstances , amid both: the COVID incidence and it's prognostic outcomes! Looking forward to read your paper! DCM

Dear Colleagues, I would like to inform that my article has now the final form and is available for free (both HTML and PDF version) at https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13748

Please read, share and cite it :)

Thank you Dr. Bleizgys for your excellent contribution!

Can COVID-19 create the vitamin D deficiency?

Yes, it can contribute to that. It is well known that inflammation (also during the COVID-19) can increase the catabolism of both 25OH-D and 1.25(OH)2-D. This results (directly and indirectly) to decrease of serum 25OH-D levels.

The usual recommended dose is a pill every 15 days, during 6 months

This question was discussed by a group of vitamin D experts who drafted this Open Letter as a result of their findings: http://vitaminDforAll.org - please consider signing the letter. The goal was to recommend high enough doses to help, but not such high doses that the letter would be dismissed out of hand by those who are fearful of toxicity.

Dear colleagues, wishing ...a Better New Year 2021 !

Our research team has just released the numbers of our vitamin D clinical snap shot survey in Montréal :

Preprint Vitamin D homeostasis in obese and diabetic groups, potentia...

In regard to the COVID-19 immunity challenge, the need for a vitamin D supplementation seem to be obvious.

Best, DCM

Please read Article Proposal of the Spanish Society of Geriatrics and Gerontolog...

Is really a good choice to try

Reza Rastmanesh, thanks for the link!

Thanks for this Spanish link on vitamin D protocols ( general & COVID-19 context ). That confirms our vitamin D previous findings and proposals in a Montréal reality :

Preprint Vitamin D homeostasis in obese and diabetic groups, potentia...

Data 3. Appendix 2-Vitamin D, an anti-infectious preventive and t...

For molecular mechanisms reasons we still believe in better outcomes with a joint vitamin D +vit A, physiologic oriented supplementation, rather than vitamin D only.

Data 4.APPENDIX 3- The Vitamin D Retinoid X Receptors tandem as i...

Best DCM

PS. They should go on public health vitamin D supplementation in India I guess !

Data 2. APENDIX 1 - Vitamin D in COVID-19 Pandemic Context Manole...

Dear Colleagues, it is my pleasure to inform You that my new article on Vit. D dosing principles and recommendations has been published:

https://www.mdpi.com/2072-6643/13/12/4415

It is importante to have this useful information and to use in many affected patients !

Thanks Dr. Bleizgys,

It is our pleasure to see our previously proposed protocol of Vitamin D (jan 2021) complements fits closely with your proposed algorhytme. Vitamin D is a must !

Preprint Vitamin D homeostasis in obese and diabetic groups, potentia...

Data 3. Appendix 2-Vitamin D, an anti-infectious preventive and t...

file:///C:/Users/umanoau/Downloads/3.Appendix2-VitaminDananti-infectiouspreventiveandtherapeuticcomplementcManolescuDCetal.2021CNSAPNM2021VitaminDhomeostasiaandCOVIDrisk.pdf

I think before and after taking vitamin D supplement the level of 25(OH)D should measured. For COVID-19 prevention I suggest to provide healthy adults with 4000 IU/D and for low vitamin D risk groups and for treatment at least we have to double the dose 8000 IU/D or taking 50,000 IU/week for 8 weeks and after that the level of 25(OH)D should be evaluated.

@Nahla Al-Bayyari, You are right, but for most outpatients having COVID-19, it is not possible to check 25OH-levels before prescribing vitamin D - they must stay at home or other place of isolation.

The usual dose for adults and preventive effect is 4000 IU7D every 2 weeks, during at least 6 months

Preprint Vitamin D homeostasis in obese and diabetic groups, potentia...

I think in winter we can go every week in Canada and Northern countries. We are low in vitamin D here as you can see in our populational studies ! Thanks, DCM

Agree with Andrius Bleizgys if is not meassured before is an adventure to give upper doses. The last Cochrane review conclude a little protective effect on pulmonary function (less dependence of artificial ventilation) but not on mortality. I think we need to be carefull giving recommendations and overall prognostic.

Dear Dr.Martínez-Vázquez and colleagues,

Our canadian clinic revue shows subtle to average chronic vitamin D deprivation in population here, the N Lat. and indoor life style beeing clear causal factors. That goes even worse in obese/diabetics with many twisted metabolic pathways, beeing clear limitative factor on propre immunity functioning. See our numbers :

Preprint Vitamin D homeostasis in obese and diabetic groups, potentia...

So, without needing direct Vit. D measurements, we can still propose a 4000 I.U. vitamin D / daily mass complementation for the 4-5 winter months we have here.

I doubt that would put anybody at vitamin D overload risk , while honest benefits could be expected on better immunitary answer, both to CoV virus and vaccines.

Anyway you don't want do be at lower Vit.D, even in the normal range, particularly when under viral attacks (COVID, flue, both ) and beeing obese-diabetic together.

Best, Daniel CM

Daniel Constantin Manolescu , agree, it is logical :) Risk of severe Vitamin D overdosing (with high hypercalcemia) in adults, indeed, is very very low! So, daily dose 4000 IU is safe and should be enough for many.

But not for all! E. g. some patients might have severe deficiency with even undetectable 25OH-D levels; I had such in my own practice. Those should take 10000 IU/d or event higher dose. For some of them, I advised to take 50000 IU twice per week 2weeks, then 50000 IU once per week.

I think that for some patients, particularly having many risk factors (obesity, elderly, a lot of remedies, digestions problems etc.) we must perform measurements of 25OH-D levels, since they need special attention and special dosages. I am family physician and I love to combine 25OH-D testing with other labs, e.g., HBA1c or lipids that are being performed regularly. This approach saves some money for the laboratory and some time for the patient :) It is the way to kill two birds with one stone :) Or, as we say in Lithuania - to shot two bunnies with one shot.

Indeed Dr. Bleizgys , it is always better when you can score twice with one shot :) That is what Dr. Dantzig G. optimisation algorhytme is about, right ? Performing a mass Vitamin D evaluation in Montréal, we have widely found a low pattern. That is of no help under T2DM, obesity, winter and the Covid 19 circumstances ! We MUST crush the ice and start administrating a, let's say 3000 IU Vit D / day as a public health back up measure in winter time, with wide metabolic benefits. That is even more urgent under COVID19 pandemic, to support immunitary system. No vit.D blood measures are needed at this step given there is no way to put peoples on harm with 3000 IU / day for 5 months, particularly when mass vitamin D data are low ! That should even be provided free of charge $ by the Public Health this 2021-2022 winter as an anti-Covid war tool, given the benefits of proper vitamin D status on prevalence, incidence, outcome and even in lowering CoV mutagenesis!

Once this first step is done, vit D supplementation dose dependent discrimination by classes of risk factors (serum level, life style and COVID ) should be observed.

That is the purpose of our FIBO-D protocole that reaches your D algorhytme too :

Data 3. Appendix 2-Vitamin D, an anti-infectious preventive and t...

But we should start acting for we are in late ! This virus loves Dantzig G. too !:)

Congrats for your work, Best, Daniel CM

74 ng/ml is a good threshold for patients with RVOT Premature Ventricular Contractions

My work on vitamin D and covid 19..indian experience.

https://www.researchgate.net/publication/353711918_Vitamin_D_deficiency_and_COVID-19_A_case-control_study_at_tertiary_care_hospital_in_India

Thanks Dr. Nimavat and coleagues

Here's some fresh data of Vitamin D concern from Montréal Canada too :

Conference Paper Insufficient Vitamin D and systemic inflammatory background,...