controlling the reactivity of diacid is quite problematic so how can we add different types of amines onto the di acid (pyridine 3,5-dicarboxylic acid)
Dear Ashish Kumar many thanks for asking this very interesting technical question. I assume that an important step will be the synthesis of monoamide intermediates which can then be converted into asymmetric diamides. In this context please have a look at the following potentially useful article in which the synthesis of monoamides and asymmetric diamides of heterocyclic dicarbocxylic acids is reported:
Direct synthesis of furan-2,5-dicarboxylic acid monoamides
Article Direct synthesis of furan-2,5-dicarboxylic acid monoamides
This paper has been posted by the authors as public full text on RG, so you can freely download it as pdf file.
I hope this gives you some initial ideas. Good luck with your work and best wishes!
Dear Ashish
I think Dr. Edelmann gave a good answer to your question. However treatment of pyridine-3,5-dicarboxylic acid with 1 eq amine will gave a mixture of mono and diamide which can be separated by chrmatographic method (size exclusion chromatography may be an excellent selection). Reaction of monoamide can then be converted to the desired asymmetric diamide. Best wishes!!
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