Hi,
Do somebody knows if it is possible to transform n-Butyl carbamate, introduced by mistake, to t-Butyl carbamate, without cleaving SEM protecting groups present in the molecule ?
Is trans-esterification a valid option ? Can it work with something like TMA (trimethyl aluminum) used for methyl esters ?
Thank you in advance for any answer.
I would recommend just starting again, rather than getting side tracked attempting to transform or remove and replace n-butyl with t-butyl, which likely would consume a large amount of your time and effort, and likely will not be very successful.
Dear Florent, I just came across this interesting question, but I assume that it is not of current interest any more as it was asked almost half a year ago. In any case I fully agree with Philip G Penketh in that it is not worth the effort trying to convert n-butyl carbamate into t-butylcarbamate. Cited below is a reference in which the transformation of benzylcarbamates into t-butylcarbamates is described, but I don't think that this is easily done with n-butyl instead of benzyl.
One-pot transformation of benzyl carbamates into t-butyl carbamates
Article ChemInform Abstract: One-Pot Transformation of Benzylcarbama...
Good luck with your research!
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