Good evening. Interesting question. There are some studies showing that final irrigation protocols with extensive use of chelating substances, as EDTA and citric acid, followed by 5% NaOCl result in destruction of collagen fibers which leads to a significant increase in the micro-roughness of the dentinal walls. But I don´t remember any research correlating microscopic observations of the dentinal walls roughness with microleakage or push-out assays. What I do remember is that some papers showed that root canal obturation performed after EDTA + 5% NaOCl had lower apical leakage than obturation performed after a EDTA + Chlorhexidine protocol. I think that with the good quality and flowability of our newer endodontic sealers, as BC-sealer, MTA Fillapex and AH-Plus, a root canal wall with higher roughness could promote an increased contact between dentin and sealer, which could benefit the obturation.