without treatment
what time is required for patient to become overt HT?the
It varies depending on the free hormone level, the weight of the person and the dose of medication used.
I think the 2013 ETA guidelines can help in answering this question:
https://doi.org/10.1159/000356507
From "Hypothyroidism and Thyroiditis", Textbook of Endocrinology, 2020 by Shlomo Melmed:
"The risk of progression from subclinical toovert hypothyroidism is most closely related to the magnitude of serum TSH elevation and the presence of anti-TPOAb. Prospective studies of women with subclinical hypothyroidism have shown rates of progression from approximately 3% to 8% per year, with the higher rates seen in individuals with initial TSH concentration greater than 10 and those with positive anti-TPOAb. Although most individuals progress slowly to overt hypothyroidism, rapid progression over weeks to months has been reported".
https://books.google.com.bn/books?id=YZ8_CwAAQBAJ&printsec=frontcover&hl=iw&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false
From the activation of the autoimmune process and the elevation of TPOAb, the stages go from euthyroidism to subclinical hypothyroidism, this time being variable, but from subclinical hypothyroidism to clinical hypothyroidism, TSH rises at a rate of increase of 5% per year. See Fig. 5 Thyroid vol 13 Number 1 January 2003 Demers and Spencer.
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