Dear,Naael Ali

There are many different types of auto-antigens in health individual which are under suppressor manner, that when uncovered may lead to production of immune response( immune reaction ) and presence of different types of auto-antibodies (because these auto- antigens are hidden or occult  antigens with latent  bioactive functioning ). For examples, sperms (components: antisperm antibody), joints synovial fluid, ovum (components) and ocular fluids when this compartments are being (conditions) associated with trauma, infections,rupture, abrasions or any pathological causes that may lead the (body) immune system to known those hidden or covered antigens and reflect to induce an auto-immunological reactions.

Good, Luck

NASEER ALMUKHTAR 

Deu to the increasing of immune response for many antigens that represent predictable Ag or chronic conditions Ag that's make immunity system memory

Dear, Dr. Naael

 Good evening, sir.And I hope you are full well, darling if you don't mind and with pleasure I want feedback about my modest answer for your serious question if it is adequate or not please.

Best, regards

NASEER ALMUKHTAR 

Hi Naael,

naturally occuring antibodies appear in an individual without any previous exposure to the target antigen. They belong to the IgM immunoglobulin subtype, and are usually directed to intracellular structures of comensal bacteria.

Their function is still not well define, and their binding affinity to the antigens is quite low. However they can either function as a first line of defense against bacterial and fungal pathogens, or perform house-keeping functions, by removing debries from normal physiological processes.

Nonetheless, certain environmental factors or stress conditions or genetic background may trigger mutations in these antibodies, and turns them into auto-reactive and pathogenic, which will involve them directly in (chronic) auto-inflammatory processes.

The best examples for naturally occuring antibodies are those that are used to classify the human blood types with the ABO system.

Hope this helped you. Best regards

In my opinion this is a witness for existing of physiological system of natural immunoglobulin-mediated regulation of self cells growth and function/

Please, find our paper on this matter in: Pathophysiology 2008; 15(3): 191-207