The use of MSLT to support a diagnosis of narcolepsy is suspect if Total Sleep Time on prior night sleep study is less than 6 hours
My query is what are the other ways to confirm the diagnosis of narcolepsy, if the Total Sleep Time is less than 6 hours in the preceding overnight PSG. Should one redo the PSG if the Total Sleep Time is lesser than 6 hours and run the MSLT again.
Looking forward for your help
before conducting PSG for narcolepsy, you need to take detailed history about the patient sleep pattern or behavior and the best way is to measure his sleep habits by actigraphy one week before coming to the sleep lab
i think it is fine if the TST 5 hrs and he has no history if sleep deprivation one week before the test
Dear Dr Mohammed A Al-Abri,
Thank you very much for the response
Best Regards
Pradeep
Interesting question. Have a look at Machine Learning and PSG in this field as techniques are being developed that are more sensitive and specific than MSLT. For example see the below paper as an example.
I hope this helps
Zhang, Z., Mayer, G., Dauvilliers, Y., Plazzi, G., Pizza, F., Fronczek, R., Santamaria, J., Partinen, M., Overeem, S., Peraita-Adrados, R. and Da Silva, A.M., 2018. Exploring the clinical features of narcolepsy type 1 versus narcolepsy type 2 from European Narcolepsy Network database with machine learning. Scientific reports, 8(1), pp.1-11.
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