The article Association of Glaucoma-Susceptible Genes to Regional Circumpapillary Retinal Nerve Fiber Layer Thickness and Visual Field Defects Article in Investigative ophthalmology & visual science 58(5):2510 · May 2017 DOI: 10.1167/iovs.16-20797 · License: CC BY-NC-ND 4.0 by Robert Rich is not the full text as described
The most common glaucoma related genetic factor is the non-functional gulonolactone (L-) oxidase, pseudogene in humans that produces ascorbic acid. IMHO all Primary Open Angle Glaucoma is directly caused by chronic suboptimal plasma ascorbate, and with the universal reduction of retinal atheroma, my practice changed from having the world´s record incidence of diagnosed POAG (the first to introduce non-contact tonometry for all over 16yrs) to having it virtually eliminated without a single further case in over ten years amongst a contact lens wearing population taking extra vitamin C. This was suppressed by two optometry journals, presumably pharmacy dependent. See Virno et al (1966) and - later confirming - Bietti (1966) Rome University Eye Clinic.