Dear Sylvie,
I discussed my interest in the biological activity of chalcones with Professor Truscott of Keele University; and Dr Tony Curtis (who is a former UMIST Doctoral alumnus).
Would you be interested in forming a link with Keele University to investigate the optical properties of chalcones that cause photoisomeration ? Our work provides very strong evidence that only the E isomer is cytotoxic meaning that light could be directed on to tissue to photoisomerise chalcones from E to Z or vice versa to selectively disrupt cell growth of cancerous cells.
Professor Truscott should be able to measure a) E chalcone phenyl-butenone lowest energy level conformations by UV vis spectroscopy for active chalcone analogues b) the frequencies of light required to control the photoisomerization of cytotoxic chalcones.
Sound interesting ? Best regards Alex
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