Hello, dear neuroscientists.
I have several patients with severe epileptic syndrome, who suffer from often condition of Status Epilepticus. It is noticed that after hard seizures and returning from Emergency these poor children express exponential growth in cognitive development: they begin to use new words, new types of lexical structures, they sing new songs and declare new poems.
It's very strange for me, but I saw this by my own eyes. How it can be?
Difficult to understand. Maybe you should go back in history: before the advent of pharmacological treatments, there were patients with epilepsy which serve mood and / or cognitive changes, which improved nicely after a spell. This motivated the introduction of electroconvulsive therapy in psychiatry. At least, it seems to follow a similar scheme.
Hello, Dirk.
Thank you for your answer. But what could be biochemical reasons for such phenomenon? Perhaps something like lots of glutamate secretion during SE, which then is used for buiding new connections in neuronets?
Dear Roma; an interesting observation. I am only aware of couple of studies documenting on the positive cognitive effects of AED (one for clobazam, the other for tegretol) treatment after pronged seizures. I am not sure whether physicians can become more aggressive & tight after encountering convulsive status epileptics !! Have you observed that in your own experience ?
I am now reading this review.
http://www.hindawi.com/journals/ert/2012/984124/
It will be nice if you can share some anonymous stories if possible.
Hello, Abdulhafeez.
I'm not really sure about AED's because one of the children, I'm observing, gets no AED's at all. The cutting of SE in his case is done by Sevoflurane narcosis (30 seconds, as I know), after what he sleeps for 15 minutes, and then goes home with his parents. This patient especially demonstrates very high developmental growth after SE. And he harbors de novo SCN1A nonsense mutation.
And a year ago particularly this patient got Clobazam, and his health state went worse and worse, so the parents made a solution to get of all medications. Now he lives without any AED's for a year, and everything goes better and better. The total number of seizures goes lesser every month.
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