How do one prepare Disulfiram in olive oil solutions?

I have read several articles mentioning the preparation of the drug disulfiram (DSF) in olive oil for oral gavage of rodents. However, in those papers, there is no description of how this is...

06 January 2021 3,810 1 View

Which procedure should I perform in an azo coupling reaction where histidine and tyrosine are used as the coupling agent?

I used L-Histidine and L-Tyrosine as coupling agent for azo coupling reaction and sodium hydroxide solution to adjust pH. Although color change was observed during the coupling, no precipitate...

26 May 2020 8,342 7 View

Clearer interpretation of error correction term?

Dear scholars, My error correction term coefficient is negative (-0.69) and statistically significant. This means that 0.69 of the long-term imbalances are removed in one year. It is OK. I want to...

27 January 2020 4,497 3 View

Vina.exe for boron atom ... how to compile from source code?

Hello, I want to dock a molecule including boron atom. Autodock is very slow so I want to use vina.exe instead of it. I change atom_constans variables in the source code. But after that I couldn't...

28 November 2019 8,972 2 View

Is there anyone how to solve ABAQUS illegal memory reference (signal 11) error in UVARM subroutine?

01 September 2019 6,557 3 View

How To Run Sander.MPI which doesn't seem in AmberTools18 package?

I installed AmberTools18 and I installed MPI libraries as well. Everthing is working but when I want to run sander parallel like this: mpirun -np 32 sander.MPI -O -i min.in -o min.out -p...

17 July 2019 10,006 7 View

How can I simplify VRP to TSP in Genetic Algorithm ?

I try to solve VRP with genetic algorithm and then from literature; I found that we can simplify VRP by classifying vehicles. (First classify vehicles and run TSP algorithm for all class.) How...

10 March 2019 4,885 7 View

Is there a way to eliminate non-spesific binding of HA-tagged proteins to M2 agarose?

Hi all, Im performing co-IP with Ha-tag protein lysates as prey. My problem is when i incubate M2 agarose + HA tagged protein lysate OR Ha-agarose+ flag-tagged protein lysate, my protein of...

21 January 2019 6,035 3 View

Which salts can be used to make ion-dipole forces in pesticides without harming plants ?

I am trying to find a good salt which i can mix with an herbicide (prosulfocarb) in order to increase its temperature level by making stronger intermolecular forces (and so reduce its volatility).

20 October 2018 8,701 2 View

How can I obtain angular force constant from gaussian?

Hi all, I am trying to generate a force field for a new molecule. I obtained bond foce constants but I don't know how to obtain angular force constants. Could you provide me a solution? Thank you.

15 March 2018 9,244 2 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

I need to image mesoporous silica nanoparticles that are in ~100 nm size and do high resolution TEM to look at mesopores. what grids should I use?

Need to image mesoporous silica nanoparticles using the TEM. Also, need high resolution TEM images to see the mesoporous structure. Kindly suggest what kind of grids to use. Thanks, Shatadru

02 March 2021 1,787 2 View

What solvent can I used for Paal Knorr reaction between 6-amino hexanoic acid and 2.5 hexanedione?

I am try to make the Paal Knorr reaction between 2.5 hexnedione and 6-amino hexanoic acid, my problem is type of solvent to use, because 6-hexaminohexanoic acid is soluble in water but I am not...

02 March 2021 4,443 2 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

How to remove DCU and HOBT from my reaction?

I am doing a acid and a chiral amino alcohol reaction using DCC and HOBT in DCM or THF? Can anyone suggest me how to remove DCU and HOBT from a reaction mixture??

28 February 2021 2,153 1 View

What is the most common number of epitopes in an multi-epitope Vaccine?

hi everyone, I'm interested in the field of vaccine design specifically multi-epitope cancer vaccines , I want to know if there is a minimum and maximum number of epitopes we could use in a...

27 February 2021 3,882 3 View

What pH condition required to coat APTES on silica coated Fe3O4?

It's a hydrolysis reaction, which may produce by either acid or base-catalyzed reaction. so can anybody help me with this, which condition is suitable for this reaction?

26 February 2021 1,760 8 View

How to increase solubility of Poly acrylic acid in Dioxane solvent?

I am working with Polyacrylic acid (100.000Da) and instead of water, I need to use another solvent (dioxane) to dissolve PAA. However, because of the high molecular weight, it's quite hard to...

25 February 2021 2,225 5 View

Why is NH4OH added in heavy metals limit test?

The limit test I'm referring to is USP method II. In this procedure you need to dropwise add 6N of NH4OH to the sample until it the pH is alkali. After that you need to dilute and add HOAc until...

23 February 2021 2,049 3 View

Is it efficient to do liquid biopsy to investigate the gene expressions of the tumor?

To do liquid biopsy and look for specific gene expressions there are so many published papers. Thera are different protocols and procedures used to isolate circulating cell free RNA or mRNA from...

23 February 2021 7,326 5 View