Many examples such as the fine structure constant exist which indicates a set of parameters that are held by natural processes in a fixed, long-term relationship. Further, many of the equations of science are in a form that one parameter is related to other parameter(s) such as the equivalence principle. Perhaps the underlying principle is that the universe is a series of "fine tuning" arrangements such as a thermostat controlling the temperature of a room a negative feedback arrangement.
But science seems to discount if not ignore the possibility of such arrangements or, perhaps, the arrangements have not been discovered.
Perhaps, the arrow-of-time (an observation) is the key to the undiscovered link. Is it worth the effort to discover these processes? Are the current equations just a piece of some larger series of feedback loops?