Thinking of journals as “low tier” or “high tier” is distracting from what you actually need to do, which is good work. Do your work as best you can, and publish in the fanciest journal that will accept your papers. Trying to over-optimize will lead to a lot of wasted time and lost productivity, which might end up hurting your chances for future jobs. And you also don’t want to give the impression that you’re more interested in the journal you publish in than in the work you do.

The main difference between a “high tier” journal and a “lower tier” one is that the high tier selects papers that have more surprising results, and are more likely to be wrong. You read that right — results in “fancy” journals such as Nature or Science are pretty often wrong, which makes sense given that they are “groundbreaking”. When doing groundbreaking work, it’s likely you’ll make a lot of mistakes; that’s the price you pay for going too far off the beaten path. Results that make it to more average journals are more mundane, but for that reason it’s also easier to make them more rigorous, and thus it’s less likely they’re wrong.

Remember also that no journal has dedicated reviewers. The people reviewing your work will be essentially the same, whether in Nature (impact factor >30) or in PLOS (impact factor about 3). So a fancy journal selects for how amazing your work sounds more than for how good it is.

That said, of course you want to stay away from the creepy “journals” that invite you to publish your work in them without getting your name right or having any idea what your work is about. It’s probably better to not publish at all than publish there. In some fields — like theoretical physics and most of math — people only really care about the results being available on a preprint server like the arXiv and don’t care where the work ends up being published. This is starting to become more popular in some areas of biology, too, with the bioRxiv (preprint server for Biology).

Another common sense thing to do is to first try publishing your work in a journal that’s just a bit fancier than you think your results are. If they reject your paper, go down the ladder. So if you’ve found a nice, new result that seems somewhat surprising, it’s worth considering submitting it to Nature or Science (or whatever the fancy journal of choice is in your field), just in case they like it. But if your work is a rather obvious extension of existing work, you might be better off heading for a more specialized journal that puts less emphasis on groundbreaking results.

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