What the exact mechanism of COVID-19 and why it's different from the other coronaviruses (MERS, SARS) in the same family?

Hi @Fares Hezam Al-Ostoot

SARS and SARS-COV-2 belongs to the Lineage-B of beta coronavirus category. Other corona viruses like MERS (belongs to the Lineage-C) HumanCov-OC43 and HumanCov-HKU1 (belongs to the lineage-A) are different in terms of their receptor binding critical amino acid residues. In SARS COV-2, there is the occurrence of amino acids substitution within the 6 critical binding sites in S1 subunit of S-Protein which shows specificity towards the ACE-2 receptor. Along with it, There's the new insertion of amino acid sequence "PRRAR" in between the S1 and S2 subunit of Spike protein which makes the occurrence of Polybasic cleavage site in corresponding to the "Furin cleavage site (Between amino acid Arginine and Serine)". Such change in the amino acid sequence makes it different If we compare it to its previous variants.

For the mechanism part, I would like to suggest you to study some research papers regarding it in terms of recent research works done. If you find the confusion in any part of that concept, then You may ask that particular question which would be feasible to answer in a facile way to us.

Hi @Christian Ventura

Here, I would like to suggest you to go through this research paper which I've attached here. The researchers have developed a novel strategy for the adequate detection of SARS COV-2 by preparing a biosensor based on the working of Gold nanoparticles under the influence of "Plasmonic Photo Thermal (PPT) effect" and "Localised surface plasmon Resonance (LSPR) sensing". I hope this will help you to seek some idea in respective to your question.

Thank you.

Gaurav answered correctly, according to me. Do check for pdf, its good.

New hypothesis by origin. It may be useful to clarify this issue. Preprint Adaptation hypothesis of the manifestation of spring viral i...