As we talking about biofortification with agronomic approaches, how selenium would be apply and what are the basic role in human body. Lets share your views.
Selenium plays a critical role in metabolism and thyroid function and helps protect your body from damage caused by oxidative stress. What's more, selenium may help boost your immune system, slow age-related mental decline, and even reduce your risk of heart disease. https://www.healthline.com/nutrition/selenium-benefits
Selenium is a trace mineral. Your body only needs it in small amounts. Selenium helps your body make special proteins, called antioxidant enzymes. These play a role in preventing cell damage https://medlineplus.gov/ency/article/002414.htm
Selenium is a component of the unusual amino acids selenocysteine and selenomethionine. In humans, selenium is a trace element nutrient that functions as cofactor for reduction of antioxidant enzymes, such as glutathione peroxidases and certain forms of thioredoxin reductase found in animals and some plants (this enzyme occurs in all living organisms, but not all forms of it in plants require selenium). https://en.m.wikipedia.org/wiki/Selenium
The glutathione peroxidase family of enzymes (GSH-Px) catalyze certain reactions that remove reactive oxygen species such as hydrogen peroxide and organic hydroperoxides:
2 GSH + H2O2----GSH-Px → GSSG + 2 H2O
The thyroid gland and every cell that uses thyroid hormone use selenium, which is a cofactor for the three of the four known types of thyroid hormone deiodinases, which activate and then deactivate various thyroid hormones and their metabolites; the iodothyronine deiodinases are the subfamily of deiodinase enzymes that use selenium as the otherwise rare amino acid selenocysteine. (Only the deiodinase iodotyrosine deiodinase, which works on the last breakdown products of thyroid hormone, does not use selenium.) https://en.m.wikipedia.org/wiki/Selenium
Selenium is one of the important elements required for proper body functioning and metabolic activities, mostly involved in reducing oxidative stress, ageing, recovery and immunity booster.
The "therapeutic index" of selenium is concerning i.e. the difference between a healthy intake and a toxic one is small. In the ketogenic dietary treatment for epilepsy that I devised for my daughter, an adequate level of selenium is obtained from including eggs for her breakfast. Brazil nuts are often recommended for their selenium content, but too many Brazil nuts as a dietary staple can lead to toxic overload.
Dar Uma Nath Shukla in addition to the useful answers provided by Arvind Singh about the role of selenium in protection against COVID-19 please also see the following important links:
1. COVID-19 and Selenium
https://seleniumselect.com/covid-19-and-selenium/
2. Selenium and viral infection: are there lessons for COVID-19?
Article Selenium and viral infection: Are there lessons for COVID-19
3. An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status
Article An Exploratory Study of Selenium Status in Normal Subjects a...