Leucine-rich repeats are present in a large number of functionally unrelated proteins. All TLR's also contain LRR but recognize different Pathogen-associated molecular patterns, or PAMPs. How does LRR play its role in TLR's and do a number or LRR have any role in function of TLR's?
http://www.sciencedirect.com/science/article/pii/S1471490603002424
hope this helps
Dear Ms Disha Chauhan,
thanks for your help. I already have this paper but i wanted to have a thorough discussion on this topic as it is still unclear how LRR play role in various ligand recognition and what is the role of different number of LRR in same TLR in different species.
thanks and regards.
"Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors" sequence analysis and comparison of function among various species.
http://www.biomedcentral.com/1471-2164/8/124
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology