Hi everyone,
I would like to know if prolongued and accumulated fatigue is related to changes (decrements) in muscle stiffness (loss of muscle tone). If possible, I need some references regarding the physiology behind this phenomena.
look at this article it may help you
http://www.sciencedirect.com/science/article/pii/S0165027097022516
That article do not mention the relation between muscle fatigue-stiffness.
Dear all,
I have read the work by Keitaro Kubo (top researcher in muscle and tendon stiffness) but I have not found in his studies a relationship between fatigued muscle and increase/decrease in muscle stiffness.
Mr. Rather, muscle fatigue is not only the accumulation of metabolites (e.g. lactate is only one of them between a wide variaty) since there is no global mechanism responsible of muscle fatigue (See Enoka and Duchateau, 2008).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375565/
Although there are not many studies on this topic, basic physiology dictates that excess muscle tone likely results from deficiencies in inhibitory neurotransmitters such as serotonin, dopamine, NE, GABA, etc. Neurotransmitters are responsible for regulating all sorts of cellular functions, such as energy production at the cellular/mitochondrial level (ATP, etc). In other words, muscle contraction is a function of the AMP/ADP/ATP cycle and ATP binding to actin/myosin heads and filaments in muscle tissue. Fatigue happens when ATP production is not keeping up with demand for muscle contraction. Perhaps you would be the perfect researcher to conduct a study, if what is currently known about muscle physiology does not answer all of your questions. Best wishes for your success on this project.
It seems to me that you are the first scientist interested in this relationship. Go on with experiments and hurry with the publication!
Indeed, a precise biochemical patholhysiology of this relationshipis is not well understood. Current studies including mine gave 'suggestive' evidence that this relationship exists. Go for it! Interesting discovery awaits! Best
Estimado Dr. Rodríguez,
Yo creo que tu pregunta es muy interesante. Yo he podido ver ésta cosa sobre mi y algunos pacientes en overtraining (actividad todos los días). Después un período de intensa actividad física he visto una pérdida de los músculos (con electical bioimpedance). Yo pensaba que esto era causado da una insuficiente asunción de las proteínas con la dieta... pero creó que otros mecanismo endocrino son juntos con esto outcome.
Podía ser interesante investigar sobre el stado hormonal de los atléticos de overtraining, porqué yo creo que un excesivo incremento de cortisol es la causa de esta pérdida de músculos.
Caro Giuseppe,
La perdita di tono è legata alla perdita di massa muscolare, ma non è sempre così. Nella mia esperienza, dopo un esercizio molto eccentrico, la rigidità delle mucose diminuisce molto, il che può essere inteso come una condizione delle proprietà contrattili del muscolo (mancanza di ritorno dell'energia elastica)
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