Protocol for the synthesis of stapled peptide using microwave?

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Any suggestions of synthetic routes which could lead to mono N-methylation of an unsaturated aliphatic primary amine, exclusively?

I am trying reductive alkylation but ending up with many unwanted products. Probably, need to fine tune conditions like pH, solvents, temperature. I followed the attached papers.

08 June 2016 349 5 View

What's the best solvent for EVA(Ethyl Vinyl Acetate) polymer?

i want to modify this polymer with nano particle and i need a good solvent before anything ...

21 December 2015 6,998 6 View

Using autodock tool is it possible to dock two different peptides at a binding site of a receptor?

I want to dock two different peptides with a receptor simultaneously. Then I need to create a PDB file of two peptides (in one PDB file) by different softwares (like avogadro), which I think is...

30 June 2015 2,519 3 View

How to overcome the interference of chlorophyll in pesticide residue analysis?

I am doing experiment in rice leaves with different rice pesticides.

13 March 2015 9,409 4 View

What is the reason of using inert atmosphere (N2) in the synthesis of fe2o3 or iron oxide nanoparticles?

nano particle

15 February 2015 6,839 4 View

What's the CRT (cathode ray tube) role in a STEM microscope?

STEM microscopy

01 February 2015 9,571 3 View

• What the possible Persistent Organic Pollutants and Heavy metals present in fluorspar, sediments, and water bodies around its mining area?

Approximate concentrations are require in compared with the WHO permissible limts

11 August 2024 2,723 1 View

Basis set and input instruction to calculate HOMO and LUMO using Orca for Imidazolium based organic salts?

Hey there, As a synthetic chemist delving into theoretical calculations for my imidazolium-based organic molecules, I would greatly appreciate any guidance on the appropriate input instructions...

09 August 2024 5,444 7 View

How to calculate CCS for Sodiated adduct ions and Multiply Charged Ions?

I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...

08 August 2024 8,329 0 View

Separation of organic acids-HPLC?

Hello What should be done to separate and identify organic acids in HPC when their RetTime is the same?Like oxalic acid with Propanoic Acid.or acids that have a very close RetTime.

07 August 2024 8,782 3 View

Could dyes amplify the spectrum of light to a specific wavelength?

I am interested to know the behavior of dyes toward light. Specifically, Blue dyes re-emit the spectrum, especially from the green zone (known as principal in LED lamps, and blue dyes are known...

05 August 2024 3,290 1 View

How to convert g/kg Humic acid dose to kg/ha?

I used humic acid at 0.044 g/kg soil in my pot experiment. But finally, I have to recommend kg/ha. Each pot's soil weight was 11 kg. What is the solution?

02 August 2024 7,186 6 View

How to improve peaks separation in HPLC?

Hi everyone, I'd like to better separate two close peaks coming from a bioconversion sample, I'm currently using a C18 KromaPhase 4,6mm Ø.I. SCHARLAU, particle size (µm): 10, pore size (Å): 100,...

30 July 2024 435 3 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Culture fibroblasts with or without FGF2?

I'm new to primary human fibroblast culture and I'm studying aging using cells from old and young donors. Some research groups have used media supplemented with FGF2, so I cultured cells in the...

29 July 2024 3,030 2 View

How can I use DFT-D3 correction ( Siesta version 5.0.1)?

Dear Siesta Users, I installed Siesta 5.0.1 and I want to use Grimme's D3 correction. According to the 5.0.1 manual, I could use a few parameters to include the D3 correction in the...

27 July 2024 5,748 0 View

Patrick Killoran

Check this paper, it has free supplementary info

https://link.springer.com/article/10.1007/s10989-010-9215-y

Anindyasundar Adak

Thanks Patrick for your suggestion. But there is nothing in ESI except a nmr.

Mauro Ginanneschi

You can possibly find some suggestion in this article: Chemical Engineering and Processing, DOI: 10.1016/j.cep.2017.02.005.