There are some services for predicting aqueous solubility of organic compounds, but there is no stable method of prediction of solubility for small molecules (there are specialized sites for protein, but that's a lot different) in organic solvents.

http://www.vcclab.org/lab/alogps/

https://disco.chemaxon.com/apps/demos/solubility/

Unforunately, there is no unified formula for solubility in organic solvents beyond basic heuristics like non-polar solvents (DCM, ether, hexane) don't dissolve ionic compounds. Or "solvents with high dipole moment can dissolve just about anything organic".

https://www.masterorganicchemistry.com/2012/04/27/polar-protic-polar-aprotic-nonpolar-all-about-solvents/

Hi Berry,

To predicte solubility for a compound you can start from the fact that says [ Like dissolve like], therefor for polar compound you are looking for polar solvent and for nonpolar compound non polar solvent...Good luck

Thanks, all! Certainly the water-solubility and water:octanol partition predictors help. I was hoping there was something that would predict in a semi-quantitative way solubility of an arbitray compound in common so,vents like hexane, dichloromethane, diethyl ether, ethylacetate, methanol etc. Apparently not.

Mr. Edward

Take a look at the Abraham's formula.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.21922

Hope it helps you.