I follow the concept of biological quantum coherence and the aspects of structured water in cells. Fullerenes might be compatible with structured cellular water.
Will Nanocarbon Onion-Like Fullerenes (NOLFs) Play a Decisive Role in the Future of Molecular Medicine? Part 1. Foundation in Fullerenes: Theoretical Application of NOLFs in the Quantum Cell
Dr. Jaeken, I think you are correct. Although pristine fullerenes exhibit non-polar hydrophobic properties; they are dielectric molecules. Panich, et al. found that hydration of CNOs reveals a significant deviation in the chemical shift from that of bulk water, which can be attributed to the diamagnetic screening effect of the conducting graphitic layers. Others have reported that under the influence of electromagnetic fields, such as found in biologic systems, they form strong dipoles that further enhances the water dipole moments similar to the dipole effects on cell water you have discussed in your work on proteins.
Pristine fullerenes have been reported to bind to the nonpolar backbones in proteins possibly contributing denaturing of the affected protein based MD simulation. (Radic et al.) As such, fullerenes functionalized with large numbers of hydroxyl groups concentrated on the surface of proteins. However, much of the in vivo experiments with pristine fullerenes fail to demonstrate negative effects and often quite the opposite. Correspondingly, highly hydrated fullerenols have mixed biological benefits compared to lower hydrated fullerenols.
Based on my reading of your work expanding on Ling’s structured water concept and protein folding there would seem to be compatible similarities that could benefit cell function. There is much we don’t know, but it is conceivable that the reversible electron affinity of pristine fullerenes aids in native conformational changes, acting similar to ATP by withdrawing electrons when under the influence of the cell’s dynamic and fluctuating EMF.
Alternating and collapsing strong fullerene dipoles would aid native conformation changes and as well as the quantum charge transfer in protein by helping to expand and collapse structured cell water. These mechanisms could help explain observed beneficial effects where damaged or dysfunctional protein and hypoxic states are expected.
I am interested in your thoughts on fullerene - protein association also.