I've read about person having ADPKD for about 12 years, but both of her parents do not have any cystic tendency in kidney.
I thought it skipped generation and her grand or grand-grand parents might have had the disease. But last night I read somewhere that ADPKD never skips generation. Right now, Is it possible that we are being misdiagnosed the disease? Is it really ADPKD or something else?
First of all, thanks a lot for your valuable comments.
As far I know this ADPKD is the result of mutation i two different genes. Now, if the mutations are not come from any of the parent, are they result of spontaneous mutation or any epigenetic factor are related with these mutations.???
Actually, the child I mentioned in my question is now a 27 years old woman and my wife. Is there any opportunity to confirm the type of CKD she has.??? You mentioned many different type of cystic diseases. Are all the forms of diseases are equally life threatening...??? How could I detect the actual disease. I think simple USG or CT scan could not identify the actual disease. What should I do..???
in about 5% of ADPKD patients, there is no family history due to high mutation rate. so it is common to find patients without any family history of ADPKD
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