Approx. 25% or more of the population carry HSV-1.
Its of course true, once immuno-compromised due to HIV it predisposes to HSV infections.
Further, as we know resistance to HIV has been documented.
For example there is documented cross protection in other viral infections: HSV-1 can interfere with the expression of Human Papillomavirus (HPV-18) genes in cells by reducing the amount of papillomaviral mRNA when they are infected concurrently with HPV and HSV.
Introspecting HSV-1 cross protection against HIV, chances seem to be very less since quite a large population is asymptomatically infected with HSV-1.
HSV-1 and -2 are antigenically similar and therefore they induce cross-reactive immunity. There is no such similarity between HSV and HIV and no cross-reactive immunity. So, HSV infected subjects are not HIV immune
Many thanks Prof. Laure for your views. It was just a wild thought out of no where.
Cheers :)
HSV immunity cannot protect against HIV infection. Moreover HSV-infected persons are more susceptible to HIV, probable due to mucosal lesions induced by HSV. There are a few epidemiological studies on this matter.
There is some evidence regarding increased susceptibility to HIV infection among those infected with HSV.
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