The selection of oxytocin)OT) is based on numerous experimental and clinical observations, which show its activity in modulating resistance to pathogens, in mitigating overall cardiovascular risk, and in acting on the production of Nitric Oxide (ON) in the lungs, which is emerging as a key therapeutic factor for the improvement of respiratory function in patients with SARS-COVID 19. Finally, OT is physiologically produced by the human body, especially in the female sex and in the age ranges that coincide with most resistant patients. In routine clinical practice, OT exhibits an excellent therapeutic index, in absence of significant adverse effects. More information is available at https://clinicaltrials.gov/ct2/show/NCT04386447.

Unfortunately this was withdrawn.

Therefore, at present, as far as I know, there are no clinical trials for this possible treatment.

Please see papers on this topic below:

Oxytocin and COVID-19 papers:

Cardiovascular protective properties of oxytocin against COVID-19

Stephani C. Wanga and Yu-Feng Wang

Life Sci. 2021 Jan 26 : 119130.

doi: 10.1016/j.lfs.2021.119130

https://www.sciencedirect.com/science/article/pii/S0024320521001156

Oxytocin May be Superior to Gliptins as a Potential Treatment for Diabetic COVID-19 Patients

Phuoc-Tan Diep

SciMedicine Journal

Doi: 10.28991/SciMedJ-2020-02-SI-10

https://scimedjournal.org/index.php/SMJ/article/view/181

Is there an underlying link between COVID-19, ACE2, oxytocin and vitamin D?

Diep P

Medical Hypotheses (2020) 110360

https://doi.org/10.1016/j.mehy.2020.110360

Hypothesis: Oxytocin is a direct COVID-19 antiviral

Phuoc-Tan Diep, Khojasta Talash, Violet Kasabri

Medical Hypotheses 145, 110329, 2020

https://doi.org/10.1016/j.mehy.2020.110329

Oxytocin as a Potential Adjuvant against COVID-19 Infection

Pratibha Thakur, Renu Shrivastava and Vinoy Kumar Shrivastava,

Endocrine, Metabolic & Immune Disorders - Drug Targets (2020) 20: 1. https://doi.org/10.2174/1871530320666200910114259

Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?

Benjamin Buemann, Donatella Marazziti and Kerstin Uvnäs-Moberg

https://www.tandfonline.com/doi/abs/10.1080/15622975.2020.1814408?journalCode=iwbp20

Oxytocin's Anti-inflammatory and Pro-immune functions in COVID-19: A Transcriptomic Signature Based Approach

Ali S. Imami et al.

https://journals.physiology.org/doi/abs/10.1152/physiolgenomics.00095.2020

Brain oxytocin: how puzzle stones from animal studies translate into psychiatry.

Grinevich, V., Neumann, I.D. Mol Psychiatry (2020). https://doi.org/10.1038/s41380-020-0802-9

Oxytocin as a potential defence against Covid-19?

Amélie Soumier and Angela Sirigu

https://www.sciencedirect.com/science/article/pii/S0306987720306800?via%3Dihub

Oxytocin, a possible treatment for COVID-19? Everything to gain, nothing to lose

Phuoc Tan Diep, Benjamin Buemann, Kerstin Uvnäs-Moberg

https://www.clinicalneuropsychiatry.org/download/oxytocin-a-possible-treatment-for-covid-19-everything-to-gain-nothing-to-lose-letter-to-the-editor-from-the-editordesk-commentary/

Why was this clinical trial withdrawn???

Thanks for your answer.

VdK

Véronique De Kok

I am sorry but I do not know the specific reasons.

Phuoc-Tan

Thanks for your reply !

I checked and I found a part of the answer :

"Recruitment Status : Withdrawn (The study was not approved by the Italian Medicines Agency (AIFA).)

First Posted : May 13, 2020 - Last Update Posted : January 14, 2021

https://clinicaltrials.gov/ct2/show/NCT04386447?term=oxytocin&cond=Covid19&draw=2&rank=1

The question is now : why was this study not approved by the Italian Medicines Agency (AIFA) ?

The answer to that question is more difficult to find !

Have a good day !

VdK