I am looking for the exact mechanism through which aluminum will replace iron in the hemoglobin and finally causes anemia.
welcome,
https://www.semanticscholar.org/paper/25-The-Molecular-Connection-Between-Aluminum-%2C-%2C-%3A-Bignucolo-Lemire/2d57ea58a0bcf4e28d3a3cb2668f2445433ff624
Please check the below given link.
https://core.ac.uk/download/pdf/81931021.pdf
Aluminium can causes hypochromic anemia, probably interfering with heme biosynthesis. However, the enzymatic level and the interference mechanism are not known. Chronic hemolysis due to increased membrane rigidity and interference in cellular peroxidative mechanisms have also been described ( Zaman K, Zaman A, Batcabe J. Hematological effects of aluminum on living organisms.Comp Biochem Physiol C. 1993 Oct;106(2):285-93.9
Dear Aluminium lodges in the bone marrow causing dyserthropoiesis and ineffective erythropoiesis causing release of immature red blood cells resulting in anaemia.
Dear Emmanuel
Your physiopathology explanation seems to me a little bizarre. I do not know of anemia caused by the NRBCs (or reticulocytes) dismission from the BM
Aluminum adjutants in vaccines stimulate Interferons, Interleukins, TGF-β and TNF-α. These cytokines, along with reactive oxygen species, have inhibitory actions on hematopoietic stem cells leading to anemia. Excessive Aluminum in plasma can also induce hemolysis. Too many aluminum loaded vaccines injected within a short period can also results in 100% transferrin saturation. Moreover, in complex ways, aluminum adjutants also increase iron deposits in the brain as noted in Alzheimer patients.
please refer the following article
Article Antioxidant activity and protective effect of bee bread (hon...
The role of aluminum in the pathogenesis of anemia in an outpatient hemodialysis population.
Article The Role of Aluminum in the Pathogenesis of Anemia in an Out...
Aluminum may cause anemia through decreased heme synthesis, decreased globulin synthesis, and increased hemolysis. Aluminum may also have a direct effect on iron metabolism: it influences absorption of iron via the intestine, it hinders iron's transport in the serum, and it displaces iron's binding to transferrin. Patients with anemia from aluminum toxicity often have increased reticulocyte counts, decreased mean corpuscular volume [MCV} , and mean corpuscular hemoglobin {MCH}.
The complete pathophysiology of aluminum related anemia remains unclear, but, it may include heme production deterioration, synthesis, probably via interference with incorporation of iron in heme.
Please refer to ( Am J Kidney Dis , 6 (5), 348-52).