What is the nature of the research endeavor(s) that generate the view that the human brain generates "new brain cells"?
The Hippocampal formation and the dentate gyrus in particular are famous for regnerating neurons in adult hood. The regeneration of dentate granule cells has been well studied in relation to stress (which impedes the growth and regeneration) and has implication for learning and memory under PTSD conditions. This work spans several decades. Can look at Bruce S. McEwen at Rockefeller University.
https://www.rockefeller.edu/our-scientists/heads-of-laboratories/863-bruce-s-mcewen/
Additionally, in small birds with seasonal mating bird song calls there is a regeneration of the birdsong brain area every year, as there is much evolutionary pressure to be light for flight and to not tax a very fast metabolism. So this is also a well known and studied field where neurogeneis takes place in adults, and is heavily related to testosterone variations across the season. One key researcher in this field that will lead to many others is Fernando Nottebohm. Oddly enhough r. Nottebohm is also located at Rockefeller University.D
https://www.rockefeller.edu/our-scientists/heads-of-laboratories/874-fernando-nottebohm/
Study suggests no new brain cells in adult human dentate gyrus (adult human hippocampus) after age 13.
Nature. 2018 Mar 7.
doi: 10.1038/nature25975. [Epub ahead of print]
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
Sorrells SF1,2, Paredes MF1,3, Cebrian-Silla A4, Sandoval K1,3, Qi D5, Kelley KW1, James D1, Mayer S1,3, Chang J6, Auguste KI2, Chang EF2, Gutierrez AJ7, Kriegstein AR1,3, Mathern GW8,9, Oldham MC1,2, Huang EJ10, Garcia-Verdugo JM4, Yang Z5, Alvarez-Buylla A1,2.
Author information
1
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California 94143, USA.
2
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143, USA.
3
Department of Neurology, University of California San Francisco, San Francisco, California 94143, USA.
4
Laboratorio de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, CIBERNED, Valencia, 46980, Spain.
5
State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
6
David Geffen School of Medicine, Department of Neurosurgery, Intellectual Development and Disabilities Research Center, University of California Los Angeles, Los Angeles, California 90095, USA.
7
Unidad de Cirugía de la Epilepsia, Hospital Universitario La Fe, Valencia 46026, Spain.
8
Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.
9
Department of Psychiatry and Biobehavioral Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA.
10
Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA.
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