Shefin Basheera
Computer Modeling
Molecular Doxing: Using programs to find compounds that can bind to a protein. Compound Library Screening: Virtual screening systems can help identify potential modulators.
Experimental Methods
Biochemical Assays: Studying the activity of a protein in the presence of different ligands and modulators. RNAi: Altering the expression of genes associated with a protein to see how this affects its interaction with a ligand.
Bioinformatics
Interaction Data Analysis: Using databases such as the Protein Data Bank to find known interactions and modulators. Comparative Analysis: Compare structure and function with known proteins and their complexes.
Hydrophobic Interaction Definition.
Protein-ligand binding changes the state of water, which can be determined by WAXS as an increase in the intensity of water scattering of the aqueous protein-ligand system.
Patent A method for measuring the parameters of the liquid-liquid p...
Modulators for a protein-ligand complex can be found by identifying ligand-binding sites through sensitive assays like PELSA, computational binding site prediction, and scoring-function-based characterization to guide rational modulator design.
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