Can anybody let me know who or what company or university can provide Can anybody let me know who or what company or university can provide mechanism of action, proof of concept and in vivo data for my patented new novel drug molecule (organic name: 1,8,8-trifluoro, 1 trifluoromethyl, 4a-(1,4,4-trifluorocyclohexyl) decalin)? Detailed information is within my article entitled "New fully metastasis inhibitor drug molecule...'' under my profile. Please help whoever can help, as a new drug company is asking me these 3 things, so that I can present these to them and license my invention to them for finally curing cancer via its development? mechanism of action, proof of concept and in vivo data for my patented new novel drug molecule (organic name: 1,8,8-trifluoro, 1 trifluoromethyl, 4a-(1,4,4-trifluorocyclohexyl) decalin)? Detailed information is within my article entitled "New fully metastasis inhibitor drug molecule...'' under my profile. Please help whoever can help, as a new drug company is asking me these 3 things, so that I can present these to them and license my invention to them for finally curing cancer via its development?
I will not be able to pay anything for this but I am giving promise and Scientific oath here, that I will monetarily reward the helper once I license my drug to the company of interest, for helping me achieve this holy goal for the sake of ending suffering of cancer patients and finally acheieving a way to most probably cure their cancer, not for my ego but for humanity and Medicine. I am honestly asking and encouraging, Please ! Help me do it.
I will be very pleased even theoretical datas are fine. Researchers please help provide these.
Thank you all,
Mustafa Pehlivan
Pharmacist and Pharmaceutical Scientist
The first thing to do would be to submit the compound to the NCI, who will screen it for free against 60 different tumor cell lines. (See link.) If it shows promising activity, you should have no trouble getting interest from the pharmaceutical industry.
https://dtp.cancer.gov/discovery_development/nci-60/
Thanks a lot sir. I will keep this link with great thanks to you. My molecule was discovered by computational softwares and as such it has never been synthesized and funding is required for its synthesis as its synthesis will cost about 30,000 dollars. Soon in October, I will attend a meeting to explain angel investors about my invention for the possibility of getting funded, and if it is okay, I will then submit the synthesized molecule to NCI via the link you have provided. Of course, in case you know any place for funding for synthesis for my compound for a guranteed process or if it can be done at your local institution or your ageeable institutions I will be pleased. Please let me know what may follow and how you would like to progress. Thank you very much for your valuable comment. I am hoping to hear from you soon.
Until now, only German company Chiroblock guaranteed synthesis for this complicated molecule, of course for about 20,000-50,000 Euros, just to let you know.
I very much doubt that anybody would invest the money and effort, based only on computational results. A much simpler molecule, even if the calcuations don't flag it as the "best", would serve to prove that the software can be relied on. At that point, perhaps, there would be interest in investigating further predictions.
The molecule activity has been theoretically validated and the same activity approval result has been reached by 4 other softwares, not just one. There are many datas available but all computational 3D and 2D, protein structural conformation, theoretical datas etc.
Thanks for your helpful comments.
Agree with James above, you definitely need to find a collaborator to first make the compound/s, the initial hit compound will likely need several rounds of SAR study for optimisation of its therapeutic and PK properties. Drug discovery is more complicated than just finding a compound.
In addition, there must actually be a way to make the compound in the lab then the factory, if not how is it possible to even use it.
Thanks a lot to everybody WHO commented and replied to my question. I would like to gladly inform you all that my molecule has entered drug development process now. This happened following the interest of a major Pharmaceutical company in USA WHO collaborated with my patent broker in USA. All the synthesis, initial testing and development will be made under that collaboration. I am very pleased this resulted in success, but thank you all for providing response anyway.
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