Hello. I'm working on my first research in our lab using 2-methacryloyloxyethyl phosphorylcholine, a monomer called mpc.
Currently, disposable glass pipettes are filled with glass wool and aluminum oxide to make simple column, and the monomer is dissolved in a minimum amount of solvent and passed through a column to remove MEHQ inhibitor. (This method was also used to remove inhibitors of other monomers from our lab in the past.) However, this does not work well. The polymerization seems to terminate in the oligomer state even if the polymerization takes place. Perhaps the polymerization terminates quickly because the inhibitor is not properly removed.
If you are involved in related research, or anyone who has proceeded polymerization through this monomer in the past, please know if you know how to remove MEHQ inhibitor from 2-methacryloyloxyethyl phosphorylcholine monomer.
(The polymerization method is RAFT polymerization, and I changed the temperature, solvent, and even the concentration of initiator. I would be grateful if anyone who could research RAFT topics could advise me.)
To remove the inhibitor there are two major techniques used without any problems:
- one is by passing the liquid monomer through a column filled with silica or alumina gels
- and the second is by washing with a concentrated solution of NaOH (4N), followed by drying (dehydrating agent) and sometimes distilled under reduced pressure.
so try the second one if you already tried the first one.
Dear all, if you wash this monomer with H2O/NaOH it will hydrolyse to the acid+alcohol, it is very sensitive to trace water or humidity. Fast Distillation under reduced pressure with a column filed with copper foils is the more recommanded procedure. Similar questios are treated within RG. My Regards
Sigma Aldrich offers inhibitor removal kits, see here:
https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Aldrich/Bulletin/al_techbull_al154.pdf
Abdelkader BOUAZIZ
Thank you for your response. But I don't know how to run it how you say it. I can't imagine what to do with filling the column with copper foil. I also don't know how to lower the pressure and distill quickly. (I have experienced the column for material separation and the short column less than 5cm using alumina.) If possible, can you explain the method more specifically?
Jürgen Wintner Thank you for your response. But the kit is too expensive for me to buy.
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