I am trying to couple my compound with terminal carboxamide amine to lysine amine. Is there any prodrug for carboxamide so that the Lysine-compound conjugate breaks down to give carboxamide?
Recent Trends in Targeted Anticancer Prodrug and ...
www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
by Y Singh - 2008 -
Prodrug and conjugate design involves the synthesis of inactive drug .... Tegafur is a slow-releasing prodrug of 5-FU, which avoids the rapid breakdown of drug in ...... FUDR to aliphatic carboxylic acid chains to improve drug permeability [134]. ... greatest in the prodrugs with lysine and arginine residues giving IC50 values ..