If i get it right, you are trying to encapsulate 7/8 molecules in the same particle as combination delivery system. 7/8 molecules seems little bit high in number, but we used micelles to deliver 2 along with a targeting moiety.

Article EGFR targeted delivery of paclitaxel and parthenolide co-loa...

Thanks M.M. Kamal i want it for topical delivery so i need a vescicle for control delivery

I don't know about 7/8 but if you are going for 3 or 4 materials you can encapsulate them separately in a PEG matrix and functionalise them with necessary ligands and connect them in another micelle and then put another functional moiety. Disadvantage of increasing too many elements is that the material becomes too unstable and there is a chance of aggregation and therefore reduction in drug diffusion attribute. You can try it but i don't know if the result is favorable.

Best wishes

Raunak Saha