This analysis, at http://www.polygenicpathways.co.uk/alzkegg.htm highlights many pathways relevant to AD (APP processing, apoptosis,oxidative stress etc) but also illustrates a crucial role for many immune related networks and pathogen defence and entry pathways. Disruption of these networks plays a key role in AD pathology
Thanks a lot to Dr Carter for all of these diagrams, but how many drugs is necessary to block all of these pathways. I propose that some of them converging, and in some part they might overlaps. For more comprehensive analysis, we have to know what is depending from what in time and space. Also, it is impossible to block all pathways by one drug, but a drug combination which will affect different pathological levels, like a house of card, may help. This is only my `descriptive way of thinking`. For something concrete we need more time and work. It is not easy to decide which components in combination are lottery winner.
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