Curcumins, curcuminoids water soluble... it is possible???
Turmeric/derivatives soluble in water can be prepared busing synthetic methodology such as curcumin, curcuphenol. See the Several research papers by R.B.Mane , et al from shivaji university. Adopt google search.
Turmeric and its derivatives are soluble in DMSO, so you could try dissolving in this first, then dilute with water to achieve the concentrations that you require.
Alternatively, you could try this link, which I came across, to a publication in which the authors routinely made water-soluble Curcumin and curcuminoid solutions:-
http://www.sciencedirect.com/science/article/pii/S0308814616311244
Turmeric/derivatives soluble in water can be prepared busing synthetic methodology such as curcumin, curcuphenol. See the Several research papers by R.B.Mane , et al from shivaji university. Adopt google search.
Dear colleagues, Zoë & Madhukar, thank you very much for your answers and for the links and references... Yes, I am familiar with most Google references.
Curcumin is soluble in DMSO. However, when you add it to aqueous media, above certain concentrations, it starts precipitating.
Curcumin does not dissolve in water at neutral pH and RT. If you must use water as your solvent, try the age old technique of heating the mixture of the solute and solvent, say up to 70-80 deg C; boiling will not harm the molecule though. Filter the heterogenous mixture to get a homogenous solution of curcumin in water. I must warn you that the concentration of the filterate is extremely minimal. Hope the attached paper would help you further. All the best with your experiments!
is soluble in organic solvents such as acetone, ethanol, DMSO and diemethylformamide. The solubility of curcumin in these solvents is approximately 1mg/ml and in acetone it is at least 20 mg/ml. So I would not suggest water as a solvent for in vivo administration. DMSO and ethanol can serve ur purpose. Alternatively you can make a suspension using Tween-80 in water for p.o. administration.
DMSO, Ethanol and Acetone are good solvents for Turmeric, in such solution the % of Curcumin may be more than other phyto chemicals. The recent finding is that, Turmeric powder whole as such with 2 to 3 % of Piper nigrum powder boiled with milk or prepared as a paste with Honey in Q.S. is more effective in therapeutics rather than Curcumin alone, this indicate that Synergistic action is important.
Dear Dr. Sonajirao Lavekar ,
Thank you very much for your answer Sir.
Yes, the synergistic effect between Piper nigrum and Turmeric in therapeutic applications has been broadly studied and there is already a common consensus among researchers in that sense. Also, it's known that Steviol increases the solubility of turmeric in ethanol. However, the amount of turmeric in solution still remains very low...
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